Research is fun
It was a cold night, I felt not so good sleep…and got up around 9. then check mail and got a good news, that I have aother coauthor paper from Germany….and I answered with my excitments:
Osborne,Very good paper, where do you submit? Thanks for adding me as a coauthor, though I contribute to nothing…It answers your curiosity 7 years ago, as we discussed together with Daniel, how is he doing now? I still have a question, is GR level the same in astrocytes and neurons? How about MR? But it’s true astrocytes are more resistant to lots of attacks. And why some cells (like neurons) are more vulnerable than others (like glias)? The more complicated, the more vulnerable? The more energy cost cells will be easier to be destroyed than less ones… Will it be test also in vivo? I also get a good news for you. I met by chance Tom, a German once worked in Lutz group and now moved to Boston to finish a phd program in the same building as I worked. and he is working on TGFbeta1 conditioned knockout mice in brain. there is an increase in proliferation…I’m thinking to test our in vitro data with this mice. By giving BDNF, TGFbeta receptor constructs in ventricle, to test the neuroproliferation and differentiation in hippocampus, will prove that BDNF function through TGFbeta pathway. What do you think?
As about the San Diego meeting, I might go only in weekend, since I’m very busy recently. Hope to meet all of you there.
Regards to all in the lab.
Jack
A new study excited me on the importance of glutamate system in schizophrenia…. I hope to pick up my old work on this field….make it my focus.
"their study showed that apparently normal individuals who posses several risk alleles within these susceptibility schizophrenia genes, have indeed minute decrements in cognitive ability such as decreased attentional capacity and worse performance on memory tasks, and alterations in schizotypal beliefs and experiences. In other words, they found that the healthy individuals who possessed the risk variants within the DNTBP1, NRG1, and DAAO genes exhibited small reductions in their cognitive performance and had atypical experiences that might be associated with schizophrenia."
"It is striking that these genes all effect the glutamate system in the brain. Glutamate is the main excitatory chemical messenger used by the cerebral cortex. Thus, this paper highlights a role for glutamate in the development of schizophrenia-like symptoms, attention deficits, and memory problems. "
