AAAAA

There was an article about the weight of the US Presidents, from which they predicts the US election now; now a new article is coming out to predict the election with Chinese zodiac…tomorrow we may find blood types, western zodiacs, Egyptian gods, Roman signs….which will be used to predict US election…who knows, fun or truth….oh, Chinese "Back Pushing Diagrams" (推背圖) may be more accurate…see see ba!

Just read an interesting article, which wrote on the new technology shapes human brain into a machine,

"They typically read no more than one or two pages of an article or book before they would “bounce” out to another site. Sometimes they’d save a long article, but there’s no evidence that they ever went back and actually read it. " It’s true for me at least….for tons of research literature I read everyday.

Are you a "pancake people" ?Another link made me simpler.

Maybe it’s an interesting book we should read: The Big Switch: Rewriting the World From Edison to Google"

To follow up the zeal of VV for movies, I decide to collect movie posters, electronic first…

No.1 : WIKTOR SADOWSKI

Read a news on Origami, share with VV: http://www.sciencedaily.com/videos/2008/0910-science_of_origami.htm

I was thinking about my research a lot recently and come out some of the exciting projects:

1. To make a schizophrenia-like model with drosophila by mutating multiple schizophrenia related genes.

2. To build a neural circuit in microchips with neural stem cells.

3. To make a math model on neural circuits affected by multiple schizophrenia related genes.

4. To turn astrocytes or Schwan cells into neurons through neural stem cells by genetic induction.

So I need to go to a fly-lab to learn tech on Drosophila first, others I can manage by myself. 

(Brainbow from Livet et al, Nature 2007, 56) 

诺悲而奖的季节，是中国愤青比较郁闷的季节，因为日本人又一口气得了两个科学奖，15：0啦。。。 不过昨天还跟VV讨论日本的武士道精神是很好的东西，日本人对待任何事情的认真态度都是中国人所不及的，科学上，政治上的不成功归根结底还是处世的哲学不同，对待错误的态度。。。同为亚洲人，日本人却没有受到儒教的束缚，过去一百年在科学技术上对世界贡献非凡，同时又保存了固有的文化，并输出到西方，实在是了不起。我们中国人反思学习了这么多年，却没见什么长进， 实在不是个好学生。。。

实际上中国目前的科技投入还是增长很快的，我的海归同学都有自己的基金，课题和实验室，不管水平如何，毕竟是个好的发展。我听说现在的学生已经不象十年前那么想出国了。我自己当年是抱着做科学家的态度来出国学习的，一波三折，在世界各地的实验室转过，现在的兴趣和动力已经没有当初那么强烈，直到今天考医生接连失利，才又反思起来。。。做研究是需要定力的，不能被各种诱惑所干扰，沉浸其中，坚持下去，终究会有成就。。。我还有好奇心，我还有求知欲，为什么要变来变去为世俗的诱惑所烦扰呢？ 武士道精神所要达到的境界恐怕是导致日本人在科学研究上成功的主要原因。。。我应该同VV同修武士道的功夫。。。

今年的化学奖格外引人注目，因为有钱学森的堂侄钱永健获奖，同时这项研究也是我们生物研究每天都用的技术。首先发现这个绿色荧光现象的日本人就是一个爱好科学，满足好奇心，不惟名利的典范。 从这点讲，为科学而科学才是真正的科学精神，就象IgNobel 奖所宣扬的那样。。。

Now in every bus station with shelter, you’ll find a poster on BIDMC, not the good one, but try to make it notorious…

There are some genetic diseases that are recessive, that means you need two copies of mutation of this gene to get disease, but in some case you benefit from the mutation if you only have one mutation copy, and the other copy is normal. These diseases genes with heterozygote advantage are:

sickle-cell anemia against malaria

cystic fibrosis against typhoid and tuberculosis

triose phosphate isomerase deficiency against oxidative stress

I met this game when reading the article by Ben Pickard:

"Schizophrenia as genetic pelmanism
If you take a brand new pack of cards and start shuffling, it is not hard to appreciate that the longer you continue, the less likely it will be that you will find a series of cards in the same order as in the beginning. The European and Asian genomes are like a pack of cards that effectively started shuffling as humans first walked “Out of Africa” some 100,000 years ago. Meiotic recombination is the shuffling process and the result is a decreasing ability to predict at the gross level what combinations of marker alleles will be found together on a chromosome. African populations, with a longer “shuffling” time and without population bottlenecks (which effectively reorder the cards) show the least predictability (“linkage disequilibrium,” LD) across their genomes."

It’s quite an interesting metaphor for this pair of comparison.  And it’s a good game. Maybe VV can write another paper on it……

According to the  DSM-IV-TR and ICD-10, I do have this schizoid personality disorder, since I satisfy more than four of the criterias. VV’s loving me might be my personality is similar to the guy in "English Patient", like what was analyzed in this article. However, it’s not so frightened situation, that I can still live peacefully and maybe happily…